Closed System Transfer Device (CSTD) is a drug-handling safety device designed to prevent the escape of hazardous drugs or vapors into the environment and block environmental

contaminants from entering the system during preparation and administration.

In healthcare settings—especially oncology pharmacies—CSTDs are widely used when handling hazardous drugs such as chemotherapy agents.

These drugs can be harmful to healthcare workers if they are exposed through aerosols, leaks, or accidental spills.

A typical CSTD system includes components such as vial adapters, syringe adapters, bag spikes, and transfer lines that create a sealed pathway between drug containers and delivery devices.

Closed pathway: Maintains a sealed system during drug transfer.
Leak and aerosol prevention: Minimizes the risk of hazardous drug exposure.
Environmental protection: Prevents outside contaminants from entering sterile drug preparations.
Compliance with safety standards: Helps healthcare facilities meet guidelines from organizations such as National Institute for Occupational Safety and Health and United States Pharmacopeia (e.g., USP <800>).

Typical Applications

Chemotherapy drug compounding
Hazardous drug transfer from vial to syringe or IV bag
Oncology drug administration in hospitals and clinics