Spherical polyvinyl alcohol (PVA) microspheres have gained FDA approval for their use in uterine artery embolization (UAE), providing effective and

minimally invasive treatment options for uterine fibroids and adenomyosis. UAE has been recognized for its ability to preserve the uterus and

fertility, aligning with the World Health Organization's (WHO) latest definition of health, which emphasizes not only physical well-being but also

mental and social aspects.

Key Features of PVA Embolic Microspheres

1. Spherical Elastic Design: The microspheres are designed to have an elastic, spherical shape that prevents catheter blockage during embolization

procedures, ensuring smooth delivery.

2. Non-degradable Material: Made from non-degradable PVA, these microspheres offer long-lasting embolization, maintaining effective blood flow

occlusion over time without degradation.

3. Precise Vascular Embedding: The microspheres conform precisely to the targeted blood vessels, creating a dense and effective embolization that

blocks blood flow to the fibroids or adenomyosis lesions with high precision.

4. Wide Range of Sizes: These microspheres come in various sizes and specifications (e.g., 300-500µm, 500-700µm), providing flexibility to meet

different clinical requirements and ensuring optimal embolization for a range of conditions.

Recommended particle size selection for microspheres used in UAE

Uterine Artery Embolization and Its' importance

Uterine artery embolization (UAE) is a highly effective treatment for uterine fibroids and adenomyosis, both of which are common in women of

childbearing age. Uterine fibroids affect approximately 20-50% of women, while adenomyosis affects 7-23%. These conditions can severely impact a

woman's quality of life, often leading to hysterectomies, which result in permanent loss of fertility. UAE, however, offers a way to treat these conditions

while preserving the uterus and the patient's fertility.

This approach aligns with the WHO's definition of health, which involves the integrity of the body, complete physiological function, and psychological

well-being. Furthermore, the Healthy China Initiative emphasizes the shift from a disease-centered to a health-centered model of care, where

treatments like UAE play a crucial role.

Clinical Cases Demonstrating UAE's Effectiveness

1. Case 1: UAE for Uterine Fibroids

   - Patient Profile: A 46-year-old woman had been diagnosed with uterine fibroids five years prior and experienced prolonged menstrual periods and

     frequent urination for four months. She opted to avoid surgery.

   - MRI Findings: Multiple nodules and masses were observed, the largest measuring 7.9 x 7.0 cm with moderate uneven enhancement.

   - Procedure: On July 6, 2018, bilateral UAE was performed using 500-700µm microspheres.

   - Outcome: Six months post-operation, the patient’s menstrual cycle normalized, and the frequent urination ceased. An enhanced MRI showed a

     reduction in the largest mass to 6.3 x 4.2 cm, with no significant enhancement seen on the scan.

2. Case 2: UAE for Adenomyosis

   - Patient Profile: A 36-year-old woman had been suffering from progressively worsening dysmenorrhea for over 20 years. Medications were ineffective,

     and she refused a hysterectomy.

   - MRI Findings: The posterior myometrium was significantly thickened, with multiple round nodules observed.

   - Procedure: On March 7, 2019, bilateral UAE was performed with microspheres ranging from 300-500µm and 500-700µm in size.

   - Outcome: Three months post-procedure, her pain score on the Visual Analogue Scale (VAS) dropped from 8 to 2. An MRI showed significant improvement

     in the myometrium with areas of reduced enhancement.

Shanghai Teamstand Corporation: A Trusted Supplier

Shanghai Teamstand Corporation supplies embolic microspheres in various sizes and specifications, supporting UAE procedures with proven effectiveness.

With international export capabilities, Teamstand ensures that high-quality microspheres are available to meet the clinical needs of hospitals and healthcare

providers globally. The company's commitment to quality and efficacy makes them a trusted partner in the medical field.

In conclusion, PVA microspheres are an advanced tool in the treatment of uterine fibroids and adenomyosis, helping women avoid invasive surgery and

preserve their fertility. As UAE becomes more widespread, the role of high-quality microspheres provided by manufacturers like Shanghai Teamstand

Corporation will continue to grow, improving the lives of countless women worldwide.